Foundayo results: the weight loss timeline
Month-by-month, based on ATTAIN-1 trial data
Quick read · 5 min
In the ATTAIN-1 trial, people on orforglipron 36mg daily lost an average of 12.4% of their body weight over 72 weeks. For a 230-lb person, that is roughly 29 lbs. The pace is similar to semaglutide but with the convenience of a daily pill instead of a weekly injection — and no food or water timing restrictions.
- •Average total loss: 12.4% at 72 weeks on 36mg
- •12mg dose: ~9.5% average loss
- •6mg dose: ~7.5% average loss
- •First 4 weeks: 1–3 lbs (titration phase)
- •Months 2–9: the fastest part of the curve
- •Typical plateau at month 12
- •Convenience: daily pill, no food timing, no water volume rules
Based on clinical trials · No rankings · Every claim linked to source
The shape of the weight loss curve
Slow start, steep middle, gradual plateau. This is the average curve from ATTAIN-1 trial.
Source: ATTAIN-1 trial (Eli Lilly, 2025) — 3,127 participants, 72 weeks, orforglipron 6/12/36mg daily vs placebo
Milestones: real pounds at each point
Averages from trial data. Individual results vary, but these give you a realistic picture of what to expect.
Weights rounded to the nearest pound. Based on starting weights of 200 lb and 250 lb.
The four phases of the year
Knowing where you are in the arc helps you manage expectations — and stops you from panicking when the scale stalls.
- •Typical loss: 2–5 lbs
- •You are still titrating up — the dose is not yet clinically active
- •Appetite starts to shift, food noise may quieten
- •Side effects (nausea, fatigue) often peak here
- •Do not measure success yet
- •The fastest phase — most of your total loss happens here
- •You have reached a clinically active dose
- •Typical loss: 1.5–2.5 lbs per week on average
- •Scale drops are less linear — some flat weeks are normal
- •This is when clothes start fitting differently
- •Loss slows to 0.5–1 lb per week on average
- •You are chasing the last few percentage points
- •Resistance training and protein become more important
- •Small plateaus (1–3 weeks of no movement) are normal
- •Your maintenance identity starts to form
- •Weight stabilises — this is the new set point, not failure
- •Your body has adapted to a lower energy state
- •Staying on treatment keeps the weight off
- •Stopping typically means regaining 50–70% within a year
- •Long-term: most people maintain their loss on-drug
The first month: managing expectations
You are on the starting dose. That dose is not designed to cause weight loss — it is designed to let your gut adapt to the drug so you do not vomit for a week straight. Weight loss really begins when you reach the first clinically active dose, which is 4–12 weeks in depending on the drug.
The scale may still move 2–5 lbs in the first month, mostly from appetite reduction and water weight. That is normal and expected. The steep part of the curve comes later.
Not everyone gets the average
Trial averages hide a wide range. Here is how participants were distributed at 68–72 weeks.
lost 15% or more
lost 10% or more
lost 5% or more
Percentages overlap — a "10% responder" is also counted in the "5% responder" group.
Hitting the plateau
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Based on clinical trials · No rankings · Every claim linked to source
Last reviewed: March 2026