What could this mean for you?
Enter your weight to see what the trial averages would mean in real terms.
What this means:
These are averages. About 1 in 3 people on tirzepatide lost more than 20% of their body weight. About 1 in 5 people on any drug lose less than 5%. Your actual result depends on dose reached, adherence, diet, exercise, and individual metabolism.
Not everyone loses the same amount
These percentages are averages. In reality, people had very different outcomes. Here is how results were spread across thousands of participants:
Semaglutide injection (Wegovy)
(1,961 people studied)Tirzepatide (Zepbound)
(2,539 people studied)Orforglipron (Foundayo)
(1,579 people studied)Notice: On tirzepatide, 57% of people lost 20% or more. On the older drugs, that number drops to 25–37%. But on any drug, about 1 in 5 people lost less than 5%.
What predicts better results?
Higher starting weight
More absolute pounds lost, though the percentage is similar. A heavier person losing 15% loses more total weight.
Reaching maximum dose
Most weight loss happens at the highest tolerated dose. If you stay at a lower dose, you'll see less dramatic results.
Resistance training + protein
Weight training (3–4 times per week) plus 60–100g protein daily preserves muscle and may boost fat loss.
Staying on treatment
Weight loss continues for 12–18 months before plateauing. Stopping early means slower, smaller results.
Bottom line
- →Averages are just averages. About 1 in 3 people do better, and about 1 in 5 lose less than 5%.
- →Give any medication at least 3–6 months at the therapeutic dose before judging results.
- →Lifestyle factors (protein, resistance training) can meaningfully improve both how much you lose and how much is fat instead of muscle.
Common questions
See how this applies to your medication
Next step most people take
Backed by evidence · Every claim linked to its source
Last reviewed: April 2026