Treatments
Prescription Treatments
All currently FDA-approved weight loss medications. Weight loss figures are from clinical trials — individual results vary.
Quick read · 3 min
Injectable GLP-1 drugs generally produce the largest weight loss in trials. Daily pills are significantly more affordable. All require a prescription — a doctor will assess whether you qualify.
Weight loss in clinical trials — at a glance
Sorted by trial result — not a ranking. Individual results vary.
Averages from clinical trials at highest approved dose. Semaglutide pill figure (16.6%) is from OASIS 4 — with full adherence. Placebo groups typically lost 1–3%. Not everyone achieves these results.
All approved treatments
Foundayo
Orforglipron
Pill — take anytime, no food rules
Foundayo
Orforglipron
Pill — take anytime, no food rules
Zepbound & Mounjaro
Tirzepatide
Highest average weight loss in trials
Zepbound & Mounjaro
Tirzepatide
Highest average weight loss in trials
Wegovy & Ozempic
Semaglutide
Proven heart benefits + pill or injection
Wegovy & Ozempic
Semaglutide
Proven heart benefits + pill or injection
Saxenda
Liraglutide
10+ years of safety data
Saxenda
Liraglutide
10+ years of safety data
Contrave
Naltrexone / Bupropion ER
Helps quiet food cravings
Contrave
Naltrexone / Bupropion ER
Helps quiet food cravings
Qsymia
Phentermine / Topiramate ER
Most affordable (~$30–80/mo)
Qsymia
Phentermine / Topiramate ER
Most affordable (~$30–80/mo)
Xenical & Alli
Orlistat
No prescription needed (OTC)
Xenical & Alli
Orlistat
No prescription needed (OTC)