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About

How this site is built

Last reviewed: September 2026

Plain Decisions is made by one person, with agentic AI tools doing the reading and the organising. This page sets out where the numbers come from, how they are checked, and what happens when something is wrong.

Who makes this

One person, going through their own weight loss journey. I am not a doctor, a dietitian, or a medical authority of any kind. Nothing here is a substitute for advice from someone who knows your health history. I built this because the information I wanted did not exist in one place. Not wellness content, not drug marketing, not journal papers I could not follow. Just what the trials found, in plain English.

The site is independently funded. There is no medical review board here, and I am not going to invent one. More about why I built it.

How the pages get written

Every page is researched and drafted using agentic AI tools. The tools read the published trials, pull out the numbers, cross-check them against FDA labelling, and write the result in plain English. The structure, the rules the writing has to follow, and the corrections are mine.

I do not hand-review every sentence of every page before it goes live. That is the honest position. It is why the correction route below matters more here than it would on a site with a newsroom behind it.

Which sources count

Numbers come from randomised controlled trials: studies where people are assigned by chance to the treatment or to a dummy treatment. They also come from systematic reviews of those trials, and from official regulatory documents. That means FDA approval letters, prescribing information, and the equivalents from other regulators.

Press releases, company claims, and social media are not used as sources for how well a treatment works or how often side effects happen. Where something like an approval date or a price can only be sourced from a manufacturer, it is labelled as such.

Every trial referenced anywhere on the site is listed in the clinical evidence library. Each entry links to the published article, so you can read it yourself.

How the numbers are checked

Every figure on the site is traced back to the specific trial it came from. That means the trial name, how many people took part, how long it ran, and what was measured. If a figure cannot be traced to a published source, it does not go on the page.

Weight loss figures are the mean change in total body weight from the start of the trial to its primary endpoint, which is its main measurement point. They are not placebo-subtracted unless the page says so. They are averages across a study population. That is why the site says “in clinical trials, participants lost” rather than what any one person will lose. Results in a trial vary widely between individuals.

Drugs that have not been approved are always labelled as investigational. The caveat goes with it: expected timelines are estimates, and the approved version of a drug can differ from the one that was tested.

What this site does not do

It does not rank treatments, name a best option, or recommend one drug over another. Which treatment fits depends on your health history, your other medications, and what your insurance covers — none of which a website knows. The job here is to put the evidence side by side so that you and a doctor have something concrete to talk about.

It also does not diagnose anything, tell you to start or stop a medication, or predict your results.

Corrections

If a number looks wrong, tell me. The same goes if a source does not say what the page claims it says, or if something has gone out of date. I will check it against the source and fix it. I read every message.

Report an error →

Recent corrections

A few examples of corrections made after a number or a claim was rechecked against its source:

  • 17 Sept 2026 — Wegovy injection cost corrected from the list price to the manufacturer’s self-pay price ($349–$399/month).
  • 18 Sept 2026 — Contrave’s opioid restriction correctly attributed to naltrexone, not bupropion.
  • 18 Sept 2026 — the Wegovy pill dose corrected to 25 mg in the oral-vs-injectable comparison (14 mg is Rybelsus).
  • 24 Sept 2026 — llms.txt summary no longer called Qsymia the cheapest option or orlistat the only over-the-counter option.
  • 24 Sept 2026 — Foundayo results page no longer described it as the first pill-based GLP-1.

How often this is reviewed

The content is re-checked against the underlying data files on every release. It is reviewed again whenever a new trial is published, a drug is approved, or a price changes. Most pages show one site-wide review date. The in-depth guides carry their own review date because they are re-checked individually.

The site was last reviewed in .

This is not medical advice

Everything here is for information only. Always talk to a qualified healthcare provider before starting, stopping, or changing any treatment.

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Built with agentic AI tools and not a substitute for medical advice

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Medical disclaimer: This website is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare provider before starting, stopping, or changing any treatment. Prices shown are United States self-pay or list prices and vary by insurance and country.