Compare Your Options
Every clinically studied approach — medications, diet, exercise, and supplements — compared side by side. Results, tolerability, cost, and effort at a glance.
Quick read · 3 min
The big picture
How the major categories compare before you look at individual options.
Broad ranges from clinical evidence. Individual results vary. Cost figures are approximate list prices.
Approved medications compared
Scroll horizontally to compare all 8 options. Figures from pivotal clinical trials.
| Zepboundtirzepatide | Wegovy inj.semaglutide | Wegovy pilloral semaglutide | Foundayoorforglipron | Saxendaliraglutide | Qsymiaphent. / top. | Contravenaltrex. / buprop. | Alli / Xenicalorlistat | |
|---|---|---|---|---|---|---|---|---|
| Known for | Highest average weight loss in trials | Proven heart benefits | Daily pill, proven heart benefits | Pill — take anytime, no food rules | 10+ years of safety data | Most affordable (~$30–80/mo) | Helps quiet food cravings | No prescription needed (OTC) |
| Weight loss (trial avg) | Up to 20.9% | Up to 14.9% | Up to 16.6% | Up to 12.4% | Up to 8% | Up to 9.8% | Up to 9.3% | Up to 8.5% |
| Real-world example | ~46 lbs (220 lb person) | ~33 lbs | ~37 lbs | ~27 lbs | ~18 lbs | ~22 lbs | ~20 lbs | ~19 lbs |
| How you take it | Weekly injection | Weekly injection | Daily pill | Daily pill | Daily injection | Daily capsule | Twice-daily tablet | 3× daily with meals |
| Approx. cost/month | $500–$1,100 | ~$1,350 | ~$149 | $149–$399 | $1,000–$1,400 | $30–$250 | $100–$400 | $40–$400 |
| Quit due to side effects | ~6% | ~7% | ~5% | ~8% | ~9% | ~13% | ~9% | ~12% |
| Prescription needed | Yes | Yes | Yes | Yes | Yes | Yes | Yes | Rx / OTC |
| FDA approved | 2023 | 2021 | 2025 | 2026 | 2014 | 2012 | 2014 | 1999 / 2007 OTC |
| Detail page | Read more → | Read more → | Read more → | Read more → | Read more → | Read more → | Read more → | Read more → |
All figures from published clinical trials at highest approved dose. Individual results vary considerably.
What matters when choosing
People tend to weigh these factors differently — there is no single right answer.
Weight loss
Ranges from ~7% to ~21% depending on treatment
Heart benefits
Some drugs have proven cardiovascular benefit
Cost
From ~$30/mo (generic pill) to ~$1,350/mo (injection)
Convenience
Daily pill, weekly injection, or with-meal timing
Side effects
Nausea is common early on — severity and duration vary
Food & hunger
How much hunger and food noise affects your daily life
These factors matter differently to different people. This site helps you understand the differences — it does not recommend a specific option.
Head-to-head comparisons
Compare by what matters to you
Not sure where to start? Our 2-minute quiz can help.
Take the quiz →Next step most people take
Based on clinical trials · No rankings · Every claim linked to source
Last reviewed: April 2026