What you'll actually pay
Brand Contrave
~$100–$400/mo
Where a generic is available
Ask your pharmacy
If your plan covers it
Varies by plan
The $100 to $400 spread is wide because pharmacy cash prices for this drug vary a lot. Ringing round is worth more here than it is for most medications.
Where Contrave sits
Detailed pricing
Brand, generic and insurance
| Option | Cost/Month | Notes |
|---|---|---|
| Brand Contrave | ~$100–$400/mo | Pharmacy retail range |
| Generic naltrexone/bupropion ER | Ask your pharmacy | Available in some markets, not all |
| With insurance | Varies by plan | Check the formulary tier and whether prior authorisation is required |
Insurance coverage reality
Coverage for weight loss medicines varies from plan to plan and many plans require prior authorisation. Contrave sits in an awkward middle: cheap enough that a cash price is realistic for some people, expensive enough that coverage still matters. Ask your insurer whether naltrexone/bupropion is on the formulary and at what tier, then compare that copay against the pharmacy cash price.
How to get the lowest cost
Ring several pharmacies
Contrave's published range runs from about $100 to $400 a month. That spread is mostly pharmacy-to-pharmacy variation, so calling round genuinely pays here.
Ask whether a generic is available
A generic naltrexone/bupropion ER exists in some markets. Ask your pharmacy whether one is available where you are.
Compare cash price to your copay
At the lower end of the range, the cash price may beat an insurance copay. Ask the pharmacy for both numbers.
Check the formulary first
Ask your insurer whether naltrexone/bupropion is listed, at what tier, and whether prior authorisation is needed.
Common questions
Written and maintained by one person · Built with agentic AI tools · Every number checked against the cited trial · Not medical advice
Price and trial sources for Naltrexone / Bupropion ER
List prices from the manufacturer and pharmacy pricing recorded in the site's cost data, last checked September 2026: a brand range of $100–$400 per month, with a generic available in some markets. The trial below is the efficacy study behind the weight loss figures quoted elsewhere on this site.
- COR-I — Naltrexone / Bupropion: 1,742 adults with obesity or overweight with comorbidities, 56 weeks. The Lancet, 2010. View source ↗
- CONTRAVE (naltrexone and bupropion extended-release tablets) FDA prescribing information — DailyMed View source ↗
Keep reading
Next step most people take
Built with agentic AI tools and not a substitute for medical advice
Last reviewed: