How GLP-1 receptor agonists work
GLP-1 drugs act in the brain to reduce appetite and in the gut to slow digestion. Plain English explanation of both pathways.
How dual agonists work (GIP + GLP-1)
Tirzepatide activates two appetite signals instead of one. Why the combination produces greater weight loss.
How triple agonists work (GLP-1 + GIP + Glucagon)
Adding a glucagon signal increases energy expenditure — attacking obesity from a third angle.
How the amylin pathway works
Amylin is a separate fullness signal from the pancreas. Why combining it with GLP-1 produces additive weight loss.
Oral vs injectable — how delivery works
Why GLP-1 drugs are hard to take orally, how SNAC technology solves this, and why small-molecule oral GLP-1s are different.
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Start with GLP-1s if you are new to this — they are the foundation of the current generation of weight loss drugs. Every other drug class in this section either builds on the GLP-1 mechanism or complements it.