Weight loss at maximum dose
Separate trials — no head-to-head data exists. Tirzepatide from a 72-week trial; orforglipron from a 68-week trial.
For a 240 lb person. Averages from separate clinical trials. Individual results vary substantially.
Monthly cost self-pay
Orforglipron is significantly cheaper than tirzepatide injection. With insurance, both are typically $25–50/month.
List prices and manufacturer self-pay programs. Insurance coverage varies.
No head-to-head trial exists. Tirzepatide data comes from a 72-week Eli Lilly trial. Orforglipron data comes from two separate Eli Lilly trials. The comparison above uses data from these separate studies, which is less definitive than a direct trial.
Beyond weight loss
Form
How they work
Side effects
Usually fades by week 8–12 in both drugs
Tirzepatide offers higher weight loss through its dual-hormone mechanism but requires weekly injections and costs 6–7x more self-pay. Orforglipron is a convenient daily pill with much lower cost, but produces lower weight loss. Neither is universally better — discuss with your doctor based on your needle comfort, budget, and weight loss goals.
Common questions
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Last reviewed: June 2026