Key facts
At a glance
The numbers you need before deciding.
~20 lbs for a 220 lb person
Some generic options available
Morning and evening — with food
About 3 in 10 people · usually temporary
Body composition breakdown not yet published
Pattern consistent with the drug class
Before you start
Learn about this treatment
Everything you'd want to know before deciding.
On treatment
Already taking this?
Practical guides for people currently on this medication.
Clinical evidence
How it compares in trials
Average weight loss % — from individual phase 3 trials
Affordability
Cost & savings
Savings options
Some generic options available. Manufacturer savings programs may apply — ask your pharmacist.
Is this right for you?
Who this tends to fit
Relevant if you
- Struggle with emotional or compulsive eating
- Prefer a pill rather than an injection
- Want modest weight loss with potential mood-related advantages
Not right if you
- You have a seizure disorder
- You currently use opioid medications
- You have an eating disorder
- You want the highest weight loss available
Safety
Important cautions
Bupropion lowers the seizure threshold — do not take if you have a seizure disorder or have had a seizure. Avoid if you drink alcohol heavily, as this further increases seizure risk.
Do not take this drug if you currently use any opioid medication (including codeine, tramadol, or opioid cough medicines) — it will trigger acute withdrawal.
Bupropion carries a boxed warning about increased suicidal thoughts in people under 25. Discuss your mental health history with your doctor before starting.
Practical guide
How to take Naltrexone / Bupropion ER
Take with food — twice daily, morning and evening
Dose is increased gradually over the first 4 weeks to reduce side effects (start with 1 tablet in the morning)
Swallow tablets whole — do not crush, chew, or break them
Do not stop suddenly — the dose should be tapered under medical supervision
Common questions